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Scie jordan ntists at Scripps Research have uncovered a critical feature that a promising new class of cancer drugs, known as CELMoDs, needs to be effective.CELMoDs are designed to attack cancer in a novel way, by binding to a regulatory protein called cereblon, which t nike high dunk hen triggers the degradation of key cancer-driving proteins. In the study, reported on November 3 inScience, researchers discovered that these drugs, in order t nike dunkpanda o work, need to cause a critical shape-change in cereblon when they bind to it. The finding enables researchers to reliably design effective CELMoDs.鈥淭here are a lot of research groups that have spent considerable time making drugs that bind very tightly to cereblon, but have then scratched their heads in puzzlement that these drugs fail to work,鈥?says study senior author Gabriel Lander, PhD, professor in the Department of Integrative Structural and Computational Biology at Scripps Research.The study鈥檚 first author was Randy Watson, PhD, a postdoctoral researcher in the L Mohammed Amer, who goes by stage name Mo Amer is an Arab-A new balance donna merican stand-up comedian. Amer came from Kuwait as a refugee and is of Palestinian descent.Best known as one third of the comedy trio "Allah Made Me Funny", Amer made his his debut in network television when he was featured on The Late Show with Stephen Colbert.In his seven-minute long stand up, the Muslim comedian took jibes at the American g adidas schuhe campus overnment and even re-visited his famous encounter with Eric Trump, the son of US President Donald Trump.鈥楾he Daily Show鈥檚鈥?Muslim correspondent tears into Trump鈥檚 鈥楳uslim ban鈥橦e started the stand-up talking about how he was 'coincidentally' upgraded for the first time in his life and ended up sitting next to Eric Trump.He pointed out the plight of having a name as common as Mohammad and still being unable to find a keychain with his na adidas campus verdi me on it and how "no one in America has shared a聽coke with [him]"Amer moved to Texas after he escaped the "first Gulf War". While he spoke English perfectly